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KMID : 0370219820260040209
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Yakhak Hoeji
1982 Volume.26 No. 4 p.209 ~ p.214
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Studies on the Acute and Subacute Toxicity of Ginseng Saponin
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李東權/Rhee, Dong-Kwon
朴昌珍/金斗河/洪淳根/朴恩希/韓龍男/Lee, Chang-Jin/Kim, Doo-Ha/Hong Soon-Keun/Park, Eun-Hee/Han, Yong-Nam
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Abstract
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Acute toxicities of purified ginseng saponin (PGS) in mice, and subacute toxicities of PGS in rats were investigated. Average lethal doses (LD50) of PGS in male mice were 270mg/kg (i.v.), 342mg/kg (i.p.), 505mg/kg (i. m.), 950mg/kg (s.c.), and more than 5, 000mg/kg (p.o.), respectively. Results of subacute toxicity of PGS was as follows. Body weight was markedly increased by administration of PGS 7.7mg/kg but side effects were shown by administration of 77mg/kg and above dose. Especially administration of PGS 240mg/kg caused a marked decrease of albumin/globulin ratio, and 28% increase of urea nitrogen in serum, as well as 33% increase of liver weight/body weight ratio.
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KEYWORD
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